I have used acetone, alcohol, liquid freon,brakekleen,mineral spirits,gasoline,lacquer thinner,prepsol,enamel reducer, etc. for years on my bare hands. They have also been submersed/covered in grease and motor oil as well too many times to count. At 50 years old I now am showing severe exczema/psoriasis and cracking of the skin. I can't attribute it directly to this but I will say I do attempt to use vinyl or latex gloves now when I think of it ahead of time when changing motor oil etc. Of course I have had metal removed from my eyes numerous times, have a hearing loss due to industrial noise,ventilation, grinding,13 years of auto racing, 60K miles of Harley riding with straight pipes, chainsaws and other industrial equipment etc. I am also blessed with arthritis, tendonitis, burcitis etc. as well. All products of a blue collar hands on lifestyle. It seems like sometimes the better something works, the more hazarous it is, and when it really works good, they stop making it.