Many years ago, we had those Large Black and Yellow bees, under our porch.
You know the kind. They hover around, and then chase you.
I was told, they drill circular holes in wood, to make their nests. After putting up with them for a few month's, we found a guy, in our local newspaper, that will take the nest's out for FREE. He told us, they extract the chemical from the nest, for anti Bee Venom.
He waited till night fall, and crawled under our back porch. Within a minute, he crawled back out, and brushed himself off, and said Sorry, your nest is much too large to remove, and away he went.
A couple days later my son and I bought 6 or 7 cans of Bee Spray, and sprayed everywhere it would reach.
Then we went into the house. We didn't use the back entrance, for a couple weeks. They were flying around crazy. After awhile we started finding Bee bodies, on our driveway. Then they were gone.