Nope, they are completely different kinds of motors. The TR3 is from 1959 where the cylinders are made to just pull out of the block. If your bearings are good you can just unbolt the rods from the crank, pull the crank and the rods and cylinders just pop out. A rebuild kit for one of these motors is $400 for a larger piston/cylinder kit. Only issue will be keeping it cooled because the larger cylinders/pistons take away from the water jackets capacity so you need a better radiator/fan combo to keep up.
I wouldn't even move a 454 motor by myself if it were complete. Way to top heavy to control alone to keep her steady. I have a buddy with a 4 wheel engine stand that has the 4 casters spead as far apart as possible, pretty nice. He's going to find it missing one of these days.